The Proteins and Cells at Interfaces Special Interest Group seeks to promote a better understanding of cell and protein interactions with biomaterial interfaces. To achieve these goals, the group organizes activities related to the evaluation of existing materials and the design of new materials to produce targeted responses by proteins and cells. Some of the topics related to proteins include: 1) relating surface chemistry to protein adsorption or specific binding and 2) studying the activation or inactivation of protein function at interfaces, including complement activation. Cell topics include: 1) the response of cells to differing chemistries and microstructures (roughness or porosity), 2) the evaluation of multiple cell and tissue response parameters (attachment, growth, migration, differentiation, inflammation, fibrosis), 3) the role of surface receptors in cell responses, and 4) all relevant cell types including bacteria. The group organizes workshops, symposia, and sessions at the Annual Meeting.